FISH, Ewing/PNET, EWSR1 (22q12) Rearrangements
Use
Detects rearrangements involving the EWSR1 gene region at chromosome 22q12, supportive of diagnoses including Ewing sarcoma, primitive neuroectodermal tumor (PNET), desmoplastic small round cell tumor, clear cell sarcoma, angiomatoid fibrous histiocytoma, extraskeletal myxoid chondrosarcoma, and myxoid liposarcoma ([mlabs.umich.edu](https://mlabs.umich.edu/tests/ewsr1-22q12-rearrangement-fish?utm_source=openai)).
Special Instructions
Not provided.
Limitations
This FISH assay detects rearrangements of EWSR1 but does not identify the fusion partner gene ([mlabs.umich.edu](https://mlabs.umich.edu/tests/ewsr1-22q12-rearrangement-fish?utm_source=openai)).
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown CNV
Copy Number Region
Result Turnaround Time
3-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit formalin‑fixed, paraffin‑embedded tumor tissue block or unstained slides (typically 3–4, 4‑5 µm) plus an H&E‑stained slide.
Storage Instructions
Store and ship at room temperature.
Causes for Rejection
Decalcified tissue or alternative fixatives may result in failed testing.
Other tests from different labs that may be relevant