Use

This test is used to diagnose members of the Ewing sarcoma family of tumors (ESFT) by detecting rearrangements involving the EWSR1 gene. However, it does not identify specific translocation partner genes. EWSR1 rearrangements are useful markers for diagnosing Ewing family of tumors and are also found in other tumors including clear cell sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma, myxoid liposarcoma, rhabdomyosarcoma, and angiomatoid fibrous histiocytoma. Thus, correlation with histopathologic and clinical findings is essential for complete interpretation.