FISH, Myeloproliferative Neoplasms (Eosinophilia)
Use
This FISH test evaluates rearrangements in PDGFRA (4q12), PDGFRB (5q33.1), and FGFR1 (8p11‑12), which are associated with myeloproliferative neoplasms presenting with eosinophilia, including hypereosinophilic syndrome. These rearrangements result in activation of tyrosine kinases and are critical to identify in patients with prominent eosinophilia for diagnostic and therapeutic decision-making. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq211?utm_source=openai))
Special Instructions
Clinical history and reason for referral, including prior therapy and transplant history, are required with the test order. Specimens must be sent to testing lab for viability determination. Do not freeze; do not reject if viability decreases in transit. ([jdos.nicholsinstitute.com](https://jdos.nicholsinstitute.com/dos/chantilly/test/621351?utm_source=openai))
Limitations
Not provided.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
3 mL (preferred); 1 mL minimum
Minimum Volume
1 mL
Container
sodium heparin (green‑top) tube; transport medium; dark/royal blue‑top or tan‑top sodium heparin tubes for bone marrow
Storage Instructions
Room temperature; do not freeze
Causes for Rejection
Frozen specimens; formalin‑fixed specimens
Other tests from different labs that may be relevant