Free κ and λ Light Chains Plus Ratio, Quantitative (Serial Monitor)
Use
The Free κ and λ Light Chains Plus Ratio is used primarily for the long-term serial monitoring of patients. It involves the quantification of free kappa and lambda light chains, as well as the kappa/lambda ratio, which are vital in the diagnosis and management of multiple myeloma and related disorders. This test aids in the assessment of disease progression or response to treatment through the analysis of serum light chains, which are proteins produced by plasma cells. Abnormalities in light chain production (either an excess of one type or an abnormal ratio) can be indicative of malignant disease, such as multiple myeloma, light chain amyloidosis, or chronic lymphocytic leukemia.
Special Instructions
The test requires submission of the patient's Social Security number for monitoring purposes. It is important to note that values obtained using different assay methods should not be used interchangeably in serial testing. Consistent use of one assay method is recommended for monitoring each patient’s course of therapy. To order this test without the serial monitoring service, a separate test code (121137) should be utilized. For comprehensive details, refer to the description of 121137.
Limitations
The kappa/lambda light chain assay should not be interpreted as absolute evidence for the presence or absence of malignant disease. Results obtained by different assay methodologies cannot be used interchangeably, emphasizing the need for consistency in the assay method used over time. Any interference or non-specific binding affecting the assay may also impact the results. It's crucial to consider all clinical findings and other test results when making diagnostic conclusions, as this test alone may not fully capture the disease status.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 57778-3
- 36916-5
- 33944-0
- 48378-4
- 80563-0
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
5 mL
Minimum Volume
2 mL
Container
Red-top tube or serum separator tube (SST)
Collection Instructions
Collect blood in a red-top tube or serum separator tube. Allow to clot, centrifuge, and then separate the serum as soon as possible. Freeze the specimen immediately after separation.
Storage Instructions
Store and ship serum frozen. Ensure that the specimen does not thaw in transit.
Causes for Rejection
Gross hemolysis; gross lipemia; specimen received not frozen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | unacceptable |
| Refrigerated | unacceptable |
| Frozen | 14 days |
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