HDL-P, Total

Casandra

Casandra Test Code LC91613Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 818542CPT Code 83704

Also known as: High-density Lipoprotein Particle Number, Total

Clinical Use

Order Test

Use

HDL-P, a measurement of total HDL particle number concentration, may be a better marker of residual risk than chemically measured high-density lipoprotein cholesterol (HDL-C, the so-called “good” cholesterol) or apolipoprotein A-1 (apoA-1, the major protein on HDL), ie, there may be a more consistent inverse association between cardiovascular endpoints and HDL-P compared with HDL-C.

Special Instructions

The test uses an NMR LipoTube (black-and-yellow-top tube) as the preferred container; however, plain red-top, lavender-top (EDTA-no gel), or green-top (heparin-no gel) tubes are acceptable alternatives. Specimens should be centrifuged by the client prior to shipment to ensure sample integrity. Patient preparation includes fasting for 12 to 14 hours prior to specimen collection.

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. Further studies are needed to clarify the role of HDL-P in clinical practice.

Test Details

Methodology

Other

Biomarkers

HDL-P (Total)

Analyte

HDL-P (Total) • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

49748-7

Result Codes

49748-7

Result Turnaround Time

2-3 days

Specimen

Serum

Volume

2 mL

Minimum Volume

1 mL

Container

NMR LipoTube (black-and-yellow-top tube) is the preferred container; plain red-top, lavender-top (EDTA-no gel), or green-top (heparin-no gel) tubes are alternatives.

Collection Instructions

Collect specimen in NMR LipoTube. Gently invert tube eight to 10 times and allow specimen to clot for 30 minutes at room temperature prior to centrifugation.

Patient Preparation

Patient should be fasting for 12 to 14 hours.

Storage Instructions

Refrigerate all acceptable tube types as soon as possible after centrifugation within 24 hours of collection. Ship on frozen cool packs. Do not store at room temperature or freeze.

Causes for Rejection

Unspun specimens, plasma/serum contaminated with red cells, citrated plasma (light blue-top tube), gross hemolysis, inappropriate container, room temperature storage > 30 hours, or specimen > 14 days old.