Use

Histoplasma Antibodies by Complement Fixation aids in the diagnosis of histoplasmosis. It is not recommended as a standalone test. For more complete serologic testing, immunodiffusion should be performed in parallel with complement fixation. A titer of 1:8 or greater is generally considered presumptive evidence of histoplasmosis. A titer of 1:32 or greater or rising titers indicate strong presumptive evidence of histoplasmosis. Cross-reactions, usually at lower titers, may occur with other fungal diseases.