Human Placental Lactogen (HPL)
Also known as: HPL
Use
The Human Placental Lactogen (HPL) test is utilized to assess placental function and fetal well-being. It is important for monitoring the health of the placenta during pregnancy, particularly in the third trimester. The measurement of HPL can aid in diagnosing placental insufficiency, intrauterine growth restriction, and other placental disorders, which can affect fetal development. HPL levels are expected to rise throughout pregnancy; abnormalities in these levels might indicate potential complications.
Special Instructions
This test requires a separate specimen as it is not performed at ARUP Laboratories. Specimens must remain critically frozen to ensure test accuracy. Sample collection should consider timing within the trimester as reference intervals vary.
Limitations
The test performance is validated by BioAgilytix Diagnostics, a CLIA certified and CAP accredited laboratory. This assay has not received FDA approval or clearance, but it can still be used for clinical diagnosis. Factors such as improper sample handling - specifically thawing and refreezing - may compromise test results. Further, variations in reference levels depend on the gestational stage, making accurate determination of pregnancy timing critical for correct interpretation.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 2104-8
Result Turnaround Time
6-13 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate from cells within 2 hours of collection. Transfer serum to transport tube and freeze immediately.
Causes for Rejection
Specimens that have been thawed and refrozen.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | 24 hours |
| Frozen | 3 months |
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