Integrated 1

Casandra

Casandra Test Code LC28389Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 017100CPT Code 84163

Also known as: Down Syndrome, Nuchal Translucency (NT), PAPP-A

Clinical Use

Order Test

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Special Instructions

Not provided.

Limitations

This screening test requires two specimens: one collected in the first trimester and one in the second trimester. The result interpretation will only be provided when the second trimester specimen is received and tested. A positive result indicates that additional diagnostic testing may be needed to confirm the presence of a neural tube defect or chromosome abnormality. The test does not screen for open spina bifida (OSB) in the first trimester.

Test Details

Methodology

Immunoassay (CLIA)

Biomarkers

Nuchal Translucency (NT)

Analyte

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

PAPP-A Value

Analyte

PAPP-A

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

49586-1 - Integrated scn Patient-Imp
12146-7 - Fet Nuchal fold Thickness US.meas
48407-1 - PAPP-A SerPl-mCnc

Result Turnaround Time

2-5 days

Specimen

Serum

Volume

3 mL

Minimum Volume

1 mL

Container

Gel-barrier tube

Collection Instructions

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.