Maternal Serum Screening, Integrated, Specimen #2, Alpha Fetoprotein, hCG, Estriol, and Inhibin A
Also known as: MS INT2
Use
This test is a second-trimester screening for trisomy 21 (Down syndrome), trisomy 18, and open neural tube defects. It requires a first-trimester specimen to be submitted previously. The test calculates the risk of these conditions by analyzing serum markers from both the first and second trimesters, with or without first-trimester nuchal translucency measurements.
Special Instructions
Not provided.
Limitations
This test was developed by ARUP Laboratories and its performance characteristics have been determined in a CLIA certified lab. It is not FDA cleared or approved. The test is not intended to be definitive; positive results should be followed by genetic counseling, level II fetal ultrasound, and possibly amniocentesis if clinically indicated.
New York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 1834-1 - AFP SerPl-mCnc
- 11778-8 - Deliv date Clin est
- 35738-4 - Inhibin A MoM SerPl
- 23883-2 - Inhibin A SerPl-mCnc
- 20450-3 - AFP MoM SerPl
- 49586-1 - Integrated scn Patient-Imp
- 19151-0 - Specimen drawn SerPl
- 21299-3 - GA method
- 44877-9 - IDDM Patient Ql
- 8670-2 - Family member diseases Hx
- 21484-1 - Mother's race
- 11878-6 - # Fetuses US
- 21612-7 - Age - Reported
- 2250-9 - u Estriol SerPl-mCnc
- 20466-9 - u Estriol MoM SerPl
- 12146-7 - Fet Nuchal fold Thickness US.meas
- 32123-2 - PAPP-A MoM SerPl
- 49089-6 - Sonographer
- 49088-8 - Sonographer name
- 34970-4 - US Date
- 49035-9 - Fet Nuchal fold MoM Thickness US.meas
- 32435-0 - Hx of Hereditary disorders
- 48407-1 - PAPP-A SerPl-mCnc
- 64234-8 - Current smoker
- 11957-8 - Fet CRL US.meas
- 11526-1 - Pathology study
- 19080-1 - HCG SerPl-aCnc
- 20465-1 - HCG MoM SerPl
- 29463-7 - Weight
- 18185-9 - GA
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect specimen in a Serum Separator Tube (SST) or Plain Red tube. Separate from cells as soon as possible or within 2 hours of collection.
Patient Preparation
Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation. The recommended time for screening is 16 to 18 weeks of gestation.
Causes for Rejection
Plasma and hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (Avoid repeated freeze/thaw cycles.) |
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