Serum Integrated 1

Casandra

Casandra Test Code LC59435Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 017200CPT Code 84163

Also known as: Down Syndrome, PAPP-A

Clinical Use

Order Test

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Special Instructions

Not provided.

Limitations

This test, only for the first trimester portion, necessitates two specimens collected across the first and second trimesters. Results are contingent on both samples being obtained and processed. As it's a screening test, a positive outcome is an indication that diagnostic testing may be needed to determine the presence of a neural tube defect or chromosomal anomaly. The performance characteristics were established by Labcorp and it is not FDA cleared or approved.

Test Details

Methodology

Immunoassay (CLIA)

Biomarkers

PAPP-A

Analyte

PAPP-A Value

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

49586-1 - Integrated scn Patient-Imp
18185-9 - GA
21299-3 - GA method
43993-5 - Age at delivery
21484-1 - Mother's race
29463-7 - Weight
11878-6 - # Fetuses US
48407-1 - PAPP-A SerPl-mCnc
77202-0 - Laboratory comment Report
11502-2 - Laboratory report

Result Turnaround Time

2-5 days

Specimen

Serum

Volume

3 mL

Minimum Volume

1 mL

Container

Gel-barrier tube

Collection Instructions

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised. Maternal serum specimens should be drawn before amniocentesis to avoid contamination with fetal blood.