Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT
Also known as: MS INT1
Use
The Maternal Serum Screening, Integrated test is a first-trimester screening test designed to assess the risk of fetal chromosomal abnormalities such as trisomy 21 (Down syndrome) and trisomy 18, as well as open neural tube defects. The test evaluates serum markers obtained during both the first and second trimesters, combined with nuchal translucency measurements when available. It provides risk assessments after the completion of second-trimester specimen testing, which includes additional serum markers like Alpha Fetoprotein, hCG, Estriol, and Inhibin A.
Special Instructions
The test requires detailed patient history and specific gestational measurements, such as crown-rump length, nuchal translucency, and the ultrasonographer's certification details if nuchal translucency measurements are performed. All patient-specific data, including gestational age, weight, and race, must be provided to complete the risk assessment accurately. Consultation with a genetic counselor is recommended if there are any uncertainties regarding the ultrasonographer's certification or other testing criteria.
Limitations
The test cannot provide final risk assessments until results from second-trimester specimen testing are available. The measurements and interpretations are based on certain assumptions and require complete and accurate patient histories and ultrasonographic data. Misleading results may occur if there are errors in gestational age calculations or if patient history forms are incomplete or inaccurate. Furthermore, the results are interim and subject to reevaluation when complete test data is obtained.
New York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 11778-8
- 49586-1
- 19151-0
- 21299-3
- 21484-1
- 11878-6
- 21612-7
- 12146-7
- 49089-6
- 49088-8
- 34970-4
- 32435-0
- 33882-2
- 48407-1
- 64234-8
- 11957-8
- 11526-1
- 18185-9
- 29463-7
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Serum separator tube (SST) or plain red.
Collection Instructions
Specimen must be drawn between 10 weeks, 0 days and 13 weeks, 6 days gestation. If gestational age is based on crown-rump length (CRL), the specimen must be collected when the CRL is between 32.4-83.9 mm. Separate from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP standard transport tube.
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma. Hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (Avoid repeated freeze/thaw cycles.) |
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