Sequential 1

Casandra

Casandra Test Code LC65453Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 017700CPT Codes 81508, 84163, 84702

Also known as: Down Syndrome, Nuchal Translucency (NT), PAPP-A

Clinical Use

Order Test

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Special Instructions

Not provided.

Limitations

Sequential screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the first trimester portion only. Result interpretation for the first trimester is provided only for screen-positive specimens. Final results require the second trimester specimen. A positive result indicates that further diagnostic testing may be necessary to determine the presence of a neural tube defect or chromosome abnormality.

Test Details

Methodology

Immunoassay (CLIA)

Biomarkers

hCG

Analyte

hCG Value

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

PAPP-A

Analyte

PAPP-A Value

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

49586-1 - Integrated scn Patient-Imp
11957-8 - Fet CRL US.meas
34970-4 - US Date
49089-6 - Sonographer
18185-9 - GA
43993-5 - Age at delivery
21484-1 - Mother's race
29463-7 - Weight
11878-6 - # Fetuses US
12146-7 - Fet Nuchal fold Thickness US.meas
49035-9 - Fet Nuchal fold MoM Thickness US.meas
19080-1 - HCG SerPl-aCnc
32166-1 - HCG adj MoM SerPl
48407-1 - PAPP-A SerPl-mCnc
76348-2 - PAPP-A adj MoM SerPl
43995-0 - Ts 21 risk Fetus
49090-4 - Fet Ts 21 risk from Mat age
43994-3 - Ts 18 risk Fetus
47223-3 - Fet Ts 18 risk from Mat age
77202-0 - Laboratory comment Report
11502-2 - Laboratory report

Result Turnaround Time

2-5 days

Specimen

Serum

Volume

3 mL

Minimum Volume

1 mL

Container

Gel-barrier tube

Collection Instructions

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.