Integrated 2

Casandra

Casandra Test Code LC35694Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 017170CPT Codes 81511, 82105, 82677, 84702, 86336

Also known as: AFP, Maternal, Down Syndrome

Clinical Use

Order Test

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Special Instructions

This test requires a preliminary specimen collected during the first trimester for the Integrated 1 test. Gestational age is calculated based on the crown-rump length provided with this initial specimen. For detailed patient information, the Maternal Prenatal Screening requisition form (0900) should be used. Additionally, it is necessary to ensure that maternal serum samples are obtained prior to amniocentesis to prevent fetal blood contamination.

Limitations

The test is dependent on two separate specimens: one from the first trimester and another from the second trimester. As a screening test, a positive result does not confirm a condition but suggests the possibility of neural tube defects or chromosomal abnormalities, prompting further diagnostic testing. Its development and performance characteristics were established by Labcorp; however, it does not have FDA clearance or approval.

Test Details

Methodology

Immunoassay (CLIA)

Biomarkers

4 targets

AFPDIAhCGuE3

LOINC Codes

Result Codes

49586-1
11957-8
34970-4
49089-6
33882-2
18185-9
29463-7
43993-5
21484-1
44877-9
11878-6
12146-7
49035-9
48407-1
76348-2
1834-1
23811-3
19080-1
32166-1
2250-9
21264-7
23883-2
36904-1
48803-1
43995-0
49090-4
43994-3
47223-3
77202-0
11502-2

Result Turnaround Time

2-5 days

Specimen

Serum

Volume

5 mL

Minimum Volume

3 mL

Container

Gel-barrier tube

Collection Instructions

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.