Integrated 2

Casandra

Casandra Test Code LC35694Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 017170CPT Codes 81511, 82105, 82677, 84702, 86336

Also known as: AFP, Maternal, Down Syndrome

Clinical Use

Order Test

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Special Instructions

Not provided.

Limitations

The test is dependent on two separate specimens: one from the first trimester and another from the second trimester. As a screening test, a positive result does not confirm a condition but suggests the possibility of neural tube defects or chromosomal abnormalities, prompting further diagnostic testing. Its development and performance characteristics were established by Labcorp; however, it does not have FDA clearance or approval.

Test Details

Methodology

Immunoassay (CLIA)

Biomarkers

4 targets

AFPDIAhCGuE3

LOINC Codes

Result Codes

49586-1 - Integrated scn Patient-Imp
11957-8 - Fet CRL US.meas
34970-4 - US Date
49089-6 - Sonographer
33882-2 - Collect Date
18185-9 - GA
29463-7 - Weight
43993-5 - Age at delivery
21484-1 - Mother's race
44877-9 - IDDM Patient Ql
11878-6 - # Fetuses US
12146-7 - Fet Nuchal fold Thickness US.meas
49035-9 - Fet Nuchal fold MoM Thickness US.meas
48407-1 - PAPP-A SerPl-mCnc
76348-2 - PAPP-A adj MoM SerPl
1834-1 - AFP SerPl-mCnc
23811-3 - AFP adj MoM SerPl
19080-1 - HCG SerPl-aCnc
32166-1 - HCG adj MoM SerPl
2250-9 - u Estriol SerPl-mCnc
21264-7 - u Estriol adj MoM SerPl
23883-2 - Inhibin A SerPl-mCnc
36904-1 - Inhibin A adj MoM SerPl
48803-1 - Neural tube defect risk Fetus
43995-0 - Ts 21 risk Fetus
49090-4 - Fet Ts 21 risk from Mat age
43994-3 - Ts 18 risk Fetus
47223-3 - Fet Ts 18 risk from Mat age
77202-0 - Laboratory comment Report
11502-2 - Laboratory report

Result Turnaround Time

2-5 days

Specimen

Serum

Volume

5 mL

Minimum Volume

3 mL

Container

Gel-barrier tube

Collection Instructions

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.