SSB (La) (ENA) Antibody, IgG
Also known as: SSB
Use
SSB (La) antibody is recommended for the differential diagnosis of systemic lupus erythematosus (SLE) and Sjogren syndrome. It is often seen in 50-60% of Sjogren syndrome cases and is very specific if it is the only extractable nuclear antigen (ENA) antibody present. Additionally, 15-25% of systemic lupus erythematosus (SLE) patients and 5-10% of those with progressive systemic sclerosis (PSS) have this antibody.
Special Instructions
The preferred panel includes SSA 52, SSA 60, and SSB antibodies, and is used for the differential diagnosis of connective tissue diseases such as SLE, Sjogren syndrome, and mixed connective tissue disease. Transfer serum to an ARUP standard transport tube promptly after collection to ensure sample quality.
Limitations
The presence of the SSB (La) antibody alone is not conclusive for diagnosis of specific conditions and must be interpreted in the context of clinical findings and other laboratory tests. Antibody presence does not distinguish between primary and secondary Sjogren syndrome, nor can it predict disease severity or progression in SLE or PSS.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 29965-1
- 29965-1
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Collect in a serum separator tube. Separate serum from cells as soon as possible or within 2 hours of collection.
Causes for Rejection
Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |
Other tests from different labs that may be relevant