Vasoactive Intestinal Polypeptide (VIP), Plasma
Also known as: VIP
Use
Measurement of vasoactive intestinal polypeptide (VIP) in plasma can aid in the detection of VIP-secreting tumors (VIPomas), particularly in patients presenting with chronic diarrheal syndromes characterized by watery diarrhea, hypokalemia, and achlorhydria. Elevated VIP levels suggest the presence of an enteropancreatic neuroendocrine tumor. Interpretation must consider clinical context and is not diagnostic in isolation. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/8150?utm_source=openai))
Special Instructions
Not provided.
Limitations
Results are method-dependent; values obtained using different assay methodologies may not be interchangeable. Absence of elevated VIP does not exclude malignancy. Immunoassay interference (e.g., HAMA or heterophile antibodies) may affect results. Results should be interpreted in the context of clinical evaluations and other diagnostic assessments. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/8150?utm_source=openai))
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
Vasoactive Intestinal Polypeptide (VIP)
Protein
LOINC Codes
- 3125-2 - VIP SerPl-mCnc
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.55 mL
Container
Lavender top (EDTA) tube
Collection Instructions
Centrifuge and aliquot plasma into a plastic vial. Freeze immediately. Fasting specimen; avoid antacids or medications affecting intestinal motility for ≥48 hours pre‑collection.
Causes for Rejection
Gross hemolysis, gross lipemia; gross icterus is acceptable (Mayo).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient: 4 hours (per ARUP) or Room Temperature: 4 hours (Mayo) |
| Refrigerated | 24 hours |
| Frozen | 90 days (Mayo) or Frozen: 3 months (ARUP) |
Other tests from different labs that may be relevant