Voltage-Gated Potassium Channel (VGKC) Complex Antibodies: Anti LGI1 and Anti CASPR2, with Reflex to Titer, Serum
Use
Voltage-Gated Potassium Channel (VGKC) antibodies (predominately Anti-LGI1 and Anti-CASPR2) are associated with paraneoplastic neurological syndromes and limbic encephalitis. These antibodies may also be found in other conditions such as acquired neurmyotonia, painful neuropathy, Morvan's syndrome, and rare tumors (eg, thymoma, small-cell lung cancer).
Special Instructions
If a reflex test is performed, additional charges and associated CPT codes may apply. Care must be taken in interpreting the results within the broader clinical context. The test should not be used as the sole diagnostic procedure without further confirmation through additional medical procedures.
Limitations
This test is not FDA-cleared or approved. It has been developed and its performance characteristics established by Labcorp independently. Results should not be solely relied upon for diagnostic decision-making without confirmation through other medically established procedures. The detection method used is not definitive and should be interpreted in conjunction with clinical findings and other laboratory tests.
Methodology
Immunoassay (Immunofluorescence)
Biomarkers
LOINC Codes
- 505356
- 505431
- 82978-8
- 82979-6
- 90831-9
- 95600-3
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Gel-barrier tube, red-top tube, serum gel tube, serum transfer tube
Storage Instructions
Room temperature
Causes for Rejection
CSF or plasma; contaminated, hemolyzed or severely lipemic specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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