Voltage-Gated Potassium Channel (VGKC) Complex Antibodies: Anti LGI1 and Anti CASPR2, With Reflex to Titer, Spinal Fluid
Also known as: Autoimmune Dementia Panel Spinal Fluid, Paraneoplastic
Use
Voltage-Gated Potassium Channel (VGKC) antibodies (predominately Anti-LGI1 and Anti-CASPR2) are associated with paraneoplastic neurological syndromes and limbic encephalitis. These antibodies may also be found in other conditions such as acquired neurmyotonia, painful neuropathy, Morvan's syndrome and rare tumors (e.g., thymoma, small-cell lung cancer).
Special Instructions
If the reflex test is performed, additional charges and CPT code(s) may apply.
Limitations
This test was developed and its performance characteristics determined by Labcorp in accordance with CLIA requirements. However, it has not been cleared or approved by the Food and Drug Administration (FDA). Therefore, users should interpret results in the context of other clinical information.
Methodology
Immunoassay (Immunofluorescence)
Biomarkers
LOINC Codes
- 90830-1
- 90820-2
- 90831-9
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2 mL
Minimum Volume
1 mL
Container
Sterile plastic tube
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; grossly lipemic; gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant