Aldosterone and Renin Direct, With Ratio

Casandra

Casandra Test Code AR33538Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3005949CPT Code 00700

Aldosterone and Renin Direct, With Ratio

Also known as: ALD/DR

Clinical Use

Order Test

Use

The "Aldosterone and Renin Direct, With Ratio" test is used to screen for and diagnose hyperaldosteronism. It measures levels of aldosterone and renin in the body, providing a calculated aldosterone/renin ratio which helps in identifying potential cases of primary aldosteronism. This test is crucial for monitoring the renin direct concentrations which may be influenced by factors such as posture and sodium intake. The test results can be significant in understanding whether a patient's aldosteronism is due to mineralocorticoid production that is independent of the renin-angiotensin system.

Special Instructions

Not provided.

Limitations

The test should not be used for patients being treated with cathepsin B, as menstruating females or those taking estrogen-containing medications may present lower renin direct concentrations, leading to falsely high aldosterone-renin ratios. Additionally, high sodium intake can suppress serum aldosterone, skewing results. It is advised to consider the Endocrine Society recommendations for patient preparation, and factors influencing test results such as medications and sodium intake need to be controlled to avoid false-positive or false-negative outcomes.

Test Details

FDA Approved