Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
Also known as: Plasma Renin Activity, LC-MS/MS, ALDO/PRA Ratio, PRA, Primary Aldosteronism
Use
The aldosterone–renin ratio (ARR) is used to screen for primary aldosteronism (PA). It helps distinguish renin-independent hypertension. Clinical interpretation employs algorithms where suppressed renin activity ( 15 indicate likely PA, per 2025 Endocrine Society guidelines.
Special Instructions
Not provided.
Limitations
Moderate to gross hemolysis, use of plasma separator tubes, or thawed specimen are unacceptable. Interpretation may be affected by timing, posture, medications, and potassium status; pre‑analytical variables can influence renin and aldosterone measurements.
Methodology
Mass Spectrometry
Biomarkers
Aldosterone/Plasma Renin Activity Ratio
SignatureAldosterone
AnalytePlasma Renin Activity
Analyte
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1.8 mL
Minimum Volume
0.8 mL
Container
EDTA (lavender‑top) tube
Collection Instructions
Collect a mid‑morning blood sample after patient upright for minimum 2 hours, then sit 5‑15 minutes before collection
Storage Instructions
Transport frozen
Causes for Rejection
Moderate to gross hemolysis; plasma collected in plasma separator tube; received thawed
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 24 hours |
| Frozen | 28 days |
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