Arbovirus Antibodies, IgG and IgM, CSF
Also known as: ARBOCSF GM
Use
This test aids in the diagnosis of infections caused by arboviruses in cerebrospinal fluid (CSF). It detects antibodies (IgG and IgM) against several arboviruses such as West Nile virus, Eastern Equine Encephalitis virus, Western Equine Encephalitis virus, and others. The presence of specific IgM antibodies indicates a current or recent infection, while IgG antibodies can suggest past or current infection. However, cross-reactivity with other related viruses in the Flaviviridae and Alphavirus families must be considered, and corresponding serologic tests may be needed for confirmation.
Special Instructions
Not provided.
Limitations
The test is not FDA-approved. Cross-reactivity is a significant constraint, especially with related arboviruses like St. Louis encephalitis virus and members of the Alphavirus family. Additionally, the presence of antibodies in CSF may result from blood contamination or serum antibodies crossing the blood-brain barrier, leading to potential false results. It is also not to be used solely for quantitative purposes without clinical correlation.
Methodology
Immunoassay (Indirect Fluorescent Antibody (IFA), ELISA)
Biomarkers
LOINC Codes
- 39572-3 - WNV IgG CSF IA-aCnc
- 39573-1 - WNV IgM CSF IA-aCnc
- 10899-3 - EEEV IgM Titr CSF IF
- 9316-1 - WEEV IgM Titr CSF IF
- 49138-1 - CEV IgG Titr CSF IF
- 21509-5 - SLEV IgG Titr CSF IF
- 10897-7 - EEEV IgG Titr CSF IF
- 9315-3 - WEEV IgG Titr CSF IF
- 49139-9 - CEV IgM Titr CSF IF
- 21510-3 - SLEV IgM Titr CSF IF
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
4 mL
Minimum Volume
2.5 mL
Container
ARUP Standard Transport Tube
Storage Instructions
Refrigerated; frozen for New York State Clients.
Causes for Rejection
Contaminated, heat-inactivated, or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours; 4 days for New York State Clients |
| Refrigerated | 2 weeks; 1 week for New York State Clients |
| Frozen | 1 year; 1 month for New York State Clients |
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