Autoimmune Encephalopathy/Dementia Panel, CSF
Also known as: AIENCDEMC
Use
This test is used to evaluate new acute-to subacute-onset encephalopathy, dementia, or cognitive impairment. It includes detecting antibodies that may occur in autoimmune neurological diseases, helping to discriminate between chronic paraneoplastic neurological disorders and other inflammatory disorders of the nervous system. It is crucial for diagnosing autoimmune and paraneoplastic encephalitis such as limbic or diencephalic encephalitis, where antibody levels serve as important markers for diagnosis and tracking therapeutic response.
Special Instructions
Not provided.
Limitations
A negative test result does not rule out a diagnosis of autoimmune neurological diseases. Results should be interpreted in context with patient's clinical history and other laboratory findings. The full spectrum of clinical disorders and tumors associated with detected antibodies continues to be defined and should involve clinical correlation.
New York Approved
Methodology
Cell-based / Cytometry
Biomarkers
LOINC Codes
- 80220-7 - NMDAR IgG Titr CSF IF
- 14247-1 - Purkinje Cells Ab CSF Ql IF
- 82732-9 - AMPAR 1+2 IgG CSF Ql IF
- 82984-6 - GABABR IgG CSF Ql IF
- 90820-2 - CASPR2 Ab CSF Ql CBA IFA
- 90830-1 - LGI1 Ab CSF Ql CBA IFA
- 53707-6 - CV2 IgG CSF Ql IB
- 42501-7 - GAD65 Ab CSF-aCnc
- 94383-7 - Glial nuc type 1 IgG CSF Ql Line blot
- 57750-2 - Amphiphysin Ab CSF Ql IB
- 94283-9 - DPPX IgG CSF Ql CBA IFA
- 96481-7 - IgLON5 IgG CSF Ql CBA IFA
- 93500-7 - mGluR1 IgG CSF Ql CBA IFA
- 107194-3 - Ma+Ta Ab CSF Ql Line blot
Result Turnaround Time
3-10 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
3 mL
Minimum Volume
1.5 mL
Container
ARUP standard transport tubes
Collection Instructions
Transfer three 1 mL CSF aliquots to ARUP standard transport tubes.
Causes for Rejection
Fluid other than CSF. Grossly hemolyzed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 1 month |
Other tests from different labs that may be relevant