Autoimmune Epilepsy Panel, CSF
Also known as: AIEPC
Use
This test is used to evaluate new acute-to-subacute onset epilepsy and incomplete seizure control of less than 2 years. It is part of a diagnostic approach for autoimmune neurological diseases, assessing antibodies that may be associated with autoimmune epilepsy. Testing is performed in both cerebrospinal fluid (CSF) and serum to maximize diagnostic yield.
Special Instructions
Not provided.
Limitations
This test might not identify all cases of autoimmune epilepsy since antibody presence can be intermittent or absent in some patients with this condition. Negative results do not rule out autoimmune encephalitis. Clinical correlation is crucial, and further diagnostic evaluation may be necessary in the context of persistent or atypical clinical presentations. The test has not been cleared or approved by the US FDA but is performed in a CLIA-certified laboratory for clinical purposes.
New York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 80220-7 - NMDAR IgG Titr CSF IF
- 14247-1 - Purkinje Cells Ab CSF Ql IF
- 82732-9 - AMPAR 1+2 IgG CSF Ql IF
- 82984-6 - GABABR IgG CSF Ql IF
- 90820-2 - CASPR2 Ab CSF Ql CBA IFA
- 90830-1 - LGI1 Ab CSF Ql CBA IFA
- 53707-6 - CV2 IgG CSF Ql IB
- 42501-7 - GAD65 Ab CSF-aCnc
- 94383-7 - Glial nuc type 1 IgG CSF Ql Line blot
- 57750-2 - Amphiphysin Ab CSF Ql IB
- 94283-9 - DPPX IgG CSF Ql CBA IFA
- 103715-9 - GABAAR IgG CSF Ql CBA IFA
- 93500-7 - mGluR1 IgG CSF Ql CBA IFA
- 107194-3 - Ma+Ta Ab CSF Ql Line blot
Result Turnaround Time
3-10 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
3 mL
Minimum Volume
1.5 mL
Container
ARUP standard transport tubes
Collection Instructions
Transfer three 1 mL aliquots of CSF to transport tubes immediately after collection.
Storage Instructions
Transport frozen; avoid repeated freeze/thaw cycles.
Causes for Rejection
Fluids other than CSF, grossly hemolyzed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 1 month |
Other tests from different labs that may be relevant