Chimerism, Additional Donor
Also known as: STR AD DON
Use
This test is used to assess donor genotype and compare it to recipient genotype prior to allogeneic hematopoietic stem cell transplant. The pre-transplant genotyping is crucial to enable post-transplant chimerism and engraftment monitoring, which is essential for monitoring patients who have undergone bone marrow transplants. The time interval between bone marrow transplantation and the testing is necessary for proper interpretation of results.
Special Instructions
Post-transplant results will be compared to pre-transplant recipient and donor genotypes, therefore, donor and recipient samples must be obtained and genotyped before the transplant event occurs.
Limitations
Diagnostic errors can occur due to rare sequence variations. The test is not cleared or approved by the U.S. Food and Drug Administration and is performed in a CLIA-certified laboratory for clinical purposes.
New York Approved
Methodology
PCR-based
Biomarkers
Result Turnaround Time
5-9 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
2 mL
Minimum Volume
1 mL
Container
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B)
Storage Instructions
Refrigerated. Also acceptable: Ambient.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 1 month |
| Frozen | Unacceptable |