Chimerism, Posttransplant, Sorted Cells (CD 56+ Cells)
Also known as: STRPOST-56
Use
This test is used for monitoring engraftment of donor cells post allogeneic stem cell transplant in patients who have undergone bone marrow transplantation. It provides correlation with clinical status and necessary consideration of the interval between transplantation and testing. It helps in assessing the presence and the percentage of donor versus recipient cells in the patient's system, which is crucial for the proper interpretation of results and to evaluate the success of the transplantation.
Special Instructions
Donor and recipient specimens must be obtained and genotyped before the transplant event occurs. It's crucial to provide information such as results and date of the patient's most recent WBC and differential counts. For bone marrow specimens intended for cell sorting, details regarding cellularity should also be provided. Each specimen and test ordered requires a unique ARUP accession number.
Limitations
The test has a limit of detection of 2 percent for the minor cell population. Diagnostic errors can occur due to rare sequence variations, which could affect the accuracy of the results. Such errors could impact the precision of the determination of donor and recipient cell percentages within the sample.
New York Approved
Methodology
PCR-based (Other)
Biomarkers
Result Turnaround Time
5-12 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
2 mL
Minimum Volume
2 mL
Container
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B)
Storage Instructions
Ship overnight. If cell sorting is required, specimens should be received within 24 hours of collection.
Causes for Rejection
Clotted or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 72 hours |
| Frozen | Unacceptable |