Chimerism, Recipient, Pretransplant
Also known as: STR_PRE
Use
The test is used to assess the genotype of a recipient prior to allogeneic hematopoietic stem cell transplantation. This pretransplant genotyping is necessary to enable monitoring of chimerism and engraftment post transplantation. It is crucial for bone marrow transplant patients, as it helps in the correlation with clinical status and consideration of the interval between transplantation and testing for accurate interpretation of results.
Special Instructions
To order this test, the Chimerism Recipient/Donor Patient History Form must be submitted. Donor and recipient specimens should be genotyped before the transplant event occurs. If the transplant has already occurred, dry buccal brushes (not bloody) are acceptable for testing.
Limitations
Diagnostic errors can occur due to rare sequence variations. Results need to be correlated with clinical status and timing between transplantation and testing. The test has not been cleared or approved by the U.S. Food and Drug Administration, but it is performed in a CLIA-certified laboratory and intended for clinical purposes.
New York Approved
Methodology
PCR-based
Biomarkers
LOINC Codes
- 31208-2
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
2 mL
Minimum Volume
1 mL
Container
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B) tube
Storage Instructions
Refrigerated. Also acceptable: Ambient.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 1 month |
| Frozen | Unacceptable |