Chromosome FISH, Prenatal
Also known as: CHR FISHP
Use
The Chromosome FISH, Prenatal test is designed for rapid detection of aneuploidy involving chromosomes X, Y, 13, 18, and 21. It is used in conjunction with chromosome studies to assess prenatal chromosomal abnormalities and potential neural tube defects. This test is important for early identification of chromosomal anomalies, allowing for informed genetic counseling and management decisions during pregnancy.
Special Instructions
Not provided.
Limitations
The Chromosome FISH, Prenatal assay does not detect structural chromosome abnormalities, mosaicism, or other numerical chromosome abnormalities beyond X, Y, 13, 18, and 21. False positive or negative results may occur, and maternal cell contamination is a possibility. This FISH analysis should not be used as a sole basis for irreversible therapeutic decisions, and further chromosome analysis is recommended for comprehensive assessment. Approximately one-third of prenatal chromosome abnormalities might not be detected by this panel. The method is not approved by the FDA and is classified as a Laboratory Developed Test (LDT).
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 0097779
- 2002211
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Amniotic Fluid
Volume
30 mL
Minimum Volume
15 mL
Container
Sterile centrifuge tubes
Storage Instructions
Do not freeze or expose to extreme temperatures; transport at room temperature.
Causes for Rejection
Frozen specimens; Bloody specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
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