Connective Tissue Disease First Line Panel with Reflex

Also known as: CTD PAN

Clinical Use

Use

This test serves as a first-line evaluation for connective tissue diseases, including mixed connective tissue disease, Sjögren syndrome, and systemic lupus erythematosus, among others. It aids in diagnosing these conditions by detecting specific autoantibodies associated with connective tissue diseases.

Special Instructions

Not provided.

Limitations

This test may show false positives or negatives under certain conditions. Analytical limitations include interference from fibrin clots or grossly hemolyzed samples. Clinical correlation is recommended if results are borderline or if other symptoms suggest undetected antibodies. Negative results do not necessarily rule out the disease, especially if clinical suspicion persists.

Test Details

New York Approved

Methodology

Immunoassay (ELISA)

Biomarkers

Double-Stranded DNA (dsDNA) Ab IgGJo-1 (Histidyl-tRNA Synthetase) Ab, IgGScleroderma (Scl-70) (ENA) Antibody, IgGSmith (ENA) Antibody, IgGSmith/RNP (ENA) Antibody, IgGSSA-52 (Ro52) (ENA) Antibody, IgGSSA-60 (Ro60) (ENA) Antibody, IgGSSB (La) (ENA) Antibody, IgG

LOINC Codes

Result Codes

18323-6 - ENA SM IgG Ser-aCnc
58465-6 - dsDNA IgG Ser Ql IA
33983-8 - U1 snRNP IgG Ser-aCnc
47322-3 - ENA Scl70 IgG Ser IA-aCnc
31625-7 - ENA SS-A IgG Ser Ql
29965-1 - ENA SS-B IgG Ser IA-aCnc
33571-1 - ENA Jo1 IgG Ser-aCnc
53019-6 - ENA SS-a 60kD Ab Ser-aCnc

Result Turnaround Time

1-5 days

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

ARUP standard transport tube

Collection Instructions

Separate from cells ASAP or within 2 hours of collection. Transfer serum to an ARUP standard transport tube.

Storage Instructions

Refrigerated. Avoid repeated freeze/thaw cycles.

Causes for Rejection

Specimen types other than those listed. Specimens containing fibrin clots. Contaminated, grossly hemolyzed, heat-inactivated, or severely lipemic specimens.