Desipramine, Serum or Plasma by Tandem Mass Spectrometry
Also known as: DESIPRAMIN
Use
This test is used to optimize dosing and monitor patient adherence for individuals undergoing therapeutic drug monitoring with Desipramine. It is crucial for ensuring that the drug's concentration remains within the therapeutic range of 100-300 ng/mL, as concentrations exceeding 500 ng/mL may lead to toxic effects, including anticholinergic effects, drowsiness, and cardiac abnormalities. Monitoring Desipramine levels helps in individualizing treatment plans, adjusting doses appropriately, and preventing adverse events associated with toxic concentrations.
Special Instructions
Not provided.
Limitations
This test specifically measures Desipramine concentration in serum or plasma and is not designed to detect or measure levels of other tricyclic antidepressants. The test's performance characteristics have been determined by ARUP Laboratories, and it is developed as a Laboratory Developed Test (LDT), meaning it has not been cleared or approved by the FDA, yet is performed in a CLIA certified laboratory. Results outside the specified reference interval should be interpreted with caution, as they might indicate non-therapeutic or toxic levels that require medical attention.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
Desipramine
Analyte
LOINC Codes
- 3531-1 - Desipramine SerPl-mCnc
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube, plain red, lavender (K2EDTA), lavender (K3EDTA), or pink (K2EDTA)
Collection Instructions
Separate from cells ASAP or within 2 hours of collection and transfer to an ARUP standard transport tube.
Patient Preparation
Serum predose (trough) draw at a steady-state concentration.
Storage Instructions
Refrigerated.
Causes for Rejection
Whole blood, Gel Separator Tubes, Light Blue (Sodium Citrate), or Yellow (SPS or ACD Solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 5 days |
| Refrigerated | 2 weeks |
| Frozen | 6 months |
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