Desipramine, Serum or Plasma by Tandem Mass Spectrometry

Casandra

Casandra Test Code AR53719Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2011487CPT Codes 0480, 80335

Desipramine, Serum or Plasma by Tandem Mass Spectrometry

Also known as: DESIPRAMIN

Clinical Use

Order Test

Use

This test is used to optimize dosing and monitor patient adherence for individuals undergoing therapeutic drug monitoring with Desipramine. It is crucial for ensuring that the drug's concentration remains within the therapeutic range of 100-300 ng/mL, as concentrations exceeding 500 ng/mL may lead to toxic effects, including anticholinergic effects, drowsiness, and cardiac abnormalities. Monitoring Desipramine levels helps in individualizing treatment plans, adjusting doses appropriately, and preventing adverse events associated with toxic concentrations.

Special Instructions

Test only measures Desipramine concentration. If Imipramine will be administered alongside, consider ordering the 'Imipramine and Desipramine, Serum and Plasma' test (test code 0090157).

Limitations

This test specifically measures Desipramine concentration in serum or plasma and is not designed to detect or measure levels of other tricyclic antidepressants. The test's performance characteristics have been determined by ARUP Laboratories, and it is developed as a Laboratory Developed Test (LDT), meaning it has not been cleared or approved by the FDA, yet is performed in a CLIA certified laboratory. Results outside the specified reference interval should be interpreted with caution, as they might indicate non-therapeutic or toxic levels that require medical attention.

Test Details

New York Approved