Casandra
Casandra Test Code QD14721Version 1 (DRAFT)
Performing Lab
Tricyclic Antidepressants ID and Quantitation
Clinical Use
Order TestUse
This test provides identification and quantitation of tricyclic antidepressants—including amitriptyline, nortriptyline, imipramine, desipramine, doxepin, nordoxepin, clomipramine, desmethylclomipramine—and totals for each drug and class. It is used for therapeutic drug monitoring, compliance assessment, and toxicology evaluation.
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
Methodology
Mass Spectrometry
Biomarkers
Amitriptyline
AnalyteAmitriptyline
Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)
Nortriptyline
AnalyteNortriptyline
Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)
Result Turnaround Time
4 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1.5 mL
Container
red‑top tube (no gel)
Patient Preparation
Collect at steady‑state trough; >12 h after dose
Causes for Rejection
Gross hemolysis; gel barrier/Serum separator tube (SST)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 5 days |
| Frozen | Not established |
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