Tricyclic Antidepressants, Quantitative, Serum or Plasma
Also known as: TADQNT SP
Use
This test is used to optimize dosing and monitor patient adherence for tricyclic antidepressants. It measures the concentration of several common tricyclic antidepressants and their metabolites in serum or plasma to ensure therapeutic levels are achieved and to avoid toxicity. The test provides therapeutic and toxic concentration ranges for drugs like amitriptyline, nortriptyline, imipramine, and their respective metabolites, helping to guide treatment adjustments for optimal efficacy and safety.
Special Instructions
For accurate test results, it's crucial to collect the specimen as a predose (trough) draw at the steady-state concentration of the medication. Serum or plasma must be separated from cells within 2 hours of collection to ensure sample integrity, and whole blood or certain types of collection tubes like gel separators are not acceptable.
Limitations
Therapeutic ranges are not established for all tricyclic antidepressants in this test, and urine concentrations do not correlate with clinical effects or toxicity. This test is not FDA cleared or approved but is developed for clinical use in a CLIA-certified laboratory. It may not detect all metabolites or forms of the drugs depending on the individual patient's metabolism and other factors.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 3335-7
- 3333-2
- 3531-1
- 3579-0
- 3582-4
- 3862-0
- 3999-0
- 9627-1
- 3690-5
- 3872-9
- 3493-4
- 3536-0
- 3491-8
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Timing of specimen collection: Predose (trough) draw at steady-state concentration. Plain red tube or lavender (K2 or K3EDTA) or pink (K2EDTA) tube is acceptable.
Storage Instructions
Refrigerated
Causes for Rejection
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 5 days |
| Refrigerated | 2 weeks |
| Frozen | 6 months |