E-Cadherin by Immunohistochemistry

Also known as: ECADH IHC

Clinical Use

Use

E-Cadherin by Immunohistochemistry (IHC) is used primarily in the evaluation of epithelial cell adhesion and differentiation. The test detects E-cadherin, a protein that is part of the cadherin superfamily, which is involved in calcium-dependent cell-cell adhesion. Loss or reduction of E-cadherin expression is associated with various types of carcinomas, including lobular breast carcinoma and diffuse gastric cancer, making it an important biomarker in the diagnostic assessment of cancer progression and prognosis.

Special Instructions

Not provided.

Limitations

This test is performed as a stain and return (technical) service only, meaning that ARUP Laboratories does not provide interpretive pathology services for this test. The performance and interpretation of the staining results are the responsibility of the pathologist at the client laboratory. Specimens submitted with non-representative tissue types or depleted specimens may lead to inaccurate or invalid results.

Test Details

New York Approved

Methodology

Immunoassay (IHC)

Biomarkers

LOINC Codes

Result Codes

94736-6 - Tissue block ID Spec

Result Turnaround Time

1-3 days

Specimen

Tissue (FFPE)

Volume

Not provided

Minimum Volume

Not provided

Container

Paraffin block or 5 unstained slides (3- to 5-micron thick sections), positively charged slides in a tissue transport kit

Collection Instructions

Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Transport tissue block or slides using a tissue transport kit.