Epstein-Barr Virus by Quantitative NAAT, Plasma
Also known as: EBVQ
Use
The Epstein-Barr Virus by Quantitative NAAT, Plasma test is used to detect and quantify the presence of Epstein-Barr virus (EBV) in plasma samples. This test is commonly used for monitoring viral load in patients who may be at risk for complications from EBV infection, such as transplant recipients. Quantifying EBV can help guide clinical decisions regarding diagnosis and treatment strategies. The assay offers improved comparability across laboratories due to international standardization but may still present some variability due to commutability issues with the standard.
Special Instructions
This test requires careful handling of specimens to ensure accurate results. Plasma must be separated from cells within 24 hours of collection and transferred to a specific ARUP standard transport tube. The minimum volume required for the test is 1 mL, although 2 mL is preferred. The importance of interpreting each viral load measurement in clinical context is stressed, especially considering potential inhibitors or viral loads below detection limits.
Limitations
The test has a quantitative range of 1.54-8.00 log IU/mL (35.0-100,000,000 IU/mL). An interpretation of "Not Detected" does not entirely rule out the presence of EBV due to potential inhibitors or concentrations below the assay's sensitivity level. While standardized to improve consistency across laboratories, the results might vary due to specific commutability issues inherent to the standard used across different laboratories.
New York Approved
Methodology
PCR-based (qPCR)
Biomarkers
LOINC Codes
- 100677-4
- 43730-1
- 5005-4
- 43730-1
- 100677-4
- 5005-4
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
1 mL
Container
ARUP standard transport tube
Collection Instructions
Separate from cells within 24 hours of collection. Transfer to an ARUP standard transport tube using ARUP Connect or contact ARUP Client Services for supplies.
Storage Instructions
Ship specimen frozen. Stability at ambient temperature is 24 hours, refrigerated up to 6 days, and frozen up to 6 months.
Causes for Rejection
Heparinized specimen, whole blood, serum, CSF, tissue, bone marrow, body fluid.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 6 days |
| Frozen | 6 months |