Extractable Nuclear Antigen Antibodies (Smith/RNP, Smith, SSA 52, SSA 60, and SSB)
Also known as: ENA ABS4
Use
This test is recommended for the differential diagnosis of systemic lupus erythematosus (SLE) and Sjogren syndrome. It detects antibodies against specific extractable nuclear antigens (ENAs) which are associated with connective tissue diseases such as Sjogren syndrome and systemic lupus erythematosus. Antibodies like Smith/RNP, Smith, SSA 52, SSA 60, and SSB are significant in identifying specific autoimmune responses in these conditions.
Special Instructions
Not provided.
Limitations
The test is not suitable for plasma or other body fluids, bacterially contaminated specimens, or severely lipemic specimens. Antibody presence can vary and may not represent the full scope of autoimmune activity in all patients. Interpret results in conjunction with clinical findings, other laboratory tests, and patient history.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 18323-6 - ENA SM IgG Ser-aCnc
- 33983-8 - U1 snRNP IgG Ser-aCnc
- 31625-7 - ENA SS-A IgG Ser Ql
- 29965-1 - ENA SS-B IgG Ser IA-aCnc
- 53019-6 - ENA SS-a 60kD Ab Ser-aCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)
Causes for Rejection
Plasma or other body fluids. Bacterially contaminated or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |
Other tests from different labs that may be relevant