Hemoglobin Evaluation Reflexive Cascade
Also known as: HB CASCADE
Use
The Hemoglobin Evaluation Reflexive Cascade is an optimal test for the initial and confirmatory diagnosis of any suspected hemoglobinopathy. Each stage of testing is directed and interpreted by a faculty hematopathologist, ensuring comprehensive evaluation. It should not be used for follow-up of an individual with a known diagnosis.
Special Instructions
Not provided.
Limitations
The test is not New York state approved. Quantitation of hemoglobin by HPLC or electrophoresis is most definitive in individuals over one year of age, and repeat testing is recommended if done earlier. Abnormal hemoglobin variants might require additional testing, which can increase the turnaround time up to 21 days.
Methodology
NGS
Biomarkers
LOINC Codes
- 21026-0 - Path Interp Bld-Imp
- 4547-6 - Hgb A1 MFr Bld
- 4551-8 - Hgb A2 MFr Bld
- 4563-3 - Hgb C MFr Bld
- 4575-7 - Hgb E MFr Bld
- 4576-5 - Hgb F MFr Bld
- 48343-8 - Hgb Other MFr Bld
- 4625-0 - Hgb S MFr Bld
- 6864-3 - Hgb S Bld Ql Soly
- 50398-7 - Narrative diagnostic report-Imp
- 13514-5 - Hgb Fract Bld Elph-Imp
- 95795-1 - HBG1 + HBG2 Full Mut Anl Bld/T Seq
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5mL
Minimum Volume
3 mL
Container
Lavender (K 2 EDTA) or pink (K 2 EDTA)
Storage Instructions
Refrigerated. Separate specimens must be submitted when multiple tests are ordered.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 1 week |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant