Parathyroid Hormone-Related Peptide (PTHrP) by LC-MS/MS, Plasma

Also known as: PTHRP

Clinical Use

Use

This test aids in the evaluation of unexplained hypercalcemia, particularly in the context of suspected hypercalcemia of malignancy. It is specifically designed to measure amino (N)- and carboxy (C)-terminus PTHrP fragments. This feature makes it especially useful because it does not get affected by these fragments often produced by patients with renal insufficiency. This specific aspect enhances its reliability in clinical scenarios where hypercalcemia's etiology needs precise elucidation, especially in the presence of possible malignant processes.

Special Instructions

Not provided.

Limitations

The test has not been cleared or approved by the U.S. Food and Drug Administration but is performed in a CLIA-certified laboratory, maintaining high standards suitable for clinical purposes. While the test does not consider amino- and carboxy-terminal fragments as interfering substances, it may be limited if gross hemolysis occurs in the sample. Specimens that have not been frozen or are not appropriately separated within the specified time may also not yield accurate results.

Test Details

New York Approved

Methodology

Mass Spectrometry

Biomarkers

Parathyroid Hormone-Related Peptide

Protein

Concentration / Level

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

15087-0 - PTH Related Prot SerPl-sCnc

Result Turnaround Time

2-6 days

Specimen

Plasma

Volume

1.5 mL

Minimum Volume

0.7 mL

Container

ARUP Standard Transport Tube

Collection Instructions

Collect using Protease Inhibitor tube (PPACK; Phe-Pro-Arg-chloromethylketone). Use a winged collection set. Mix well and separate from cells within 1 hour of collection.