Risperidone and Metabolite, Serum or Plasma
Also known as: RISPERIDON
Use
The test is designed to optimize drug therapy and monitor patient adherence by detecting risperidone (parent) and paliperidone (9-hydroxyrisperidone, metabolite) in serum or plasma. It helps in ensuring the therapeutic range is achieved for effective treatment while minimizing toxic effects. Adverse effects to risperidone therapy may include headache, nausea, dizziness, tachycardia, orthostatic hypotension, and dyskinesia.
Special Instructions
Collect pre-dose (trough) sample after reaching steady-state concentration. Preferred collection in a plain red, lavender (EDTA), or pink (K2EDTA) tube. Separate serum or plasma from cells as soon as possible or within 2 hours of collection. Transfer at least 1 mL to ARUP Standard Transport Tube. Do not use gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Limitations
This test has been developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration, but is intended for clinical use. Whole blood and specific tube types (gel separator tubes, light blue, or yellow tubes) are not acceptable for this test. Results are based on pre-dose (trough) draw at steady-state concentration. The therapeutic range is 20-60 ng/mL for each compound, with toxicity above 120 ng/mL for combined measurements of risperidone and metabolite.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 9383-1
- 9393-0
- 9394-8
- 9393-0
- 9383-1
- 9394-8
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect in plain red, lavender (EDTA), or pink (K2EDTA) tube. Separate from cells ASAP or within 2 hours of collection.
Patient Preparation
Pre-dose (trough) draw at steady state concentration.
Storage Instructions
Refrigerated.
Causes for Rejection
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 weeks |
| Refrigerated | 2 weeks |
| Frozen | 2 months |