Zinc Protoporphyrin (ZPP), Whole Blood Industrial
Also known as: ZPP IND
Use
Zinc Protoporphyrin (ZPP) testing in whole blood is used as an OSHA-mandated indicator to assess lead exposure in the industrial setting. Elevated ZPP results can be indicative of lead poisoning or other conditions such as early and late iron deficiency, anemia of chronic disease, and erythropoietic protoporphyria. The test results help in occupational exposure assessment, where OSHA requires ZPP whole blood concentration to be reported in specific units. This information is critical for ensuring workplace safety and regulatory compliance.
Special Instructions
Not provided.
Limitations
Elevated bilirubin or riboflavin, as well as hemolyzed, clotted or improperly aliquoted specimens, may falsely increase the ZPP concentration. The test is specifically designed to measure ZPP in whole blood and assumes a hematocrit of 45% when converting ZPP to units of ug/dL for adults. The performance characteristics of this test determined by ARUP have not been compared to results from extraction-based methods or the AVIV ZPP system.
New York Approved
Methodology
Automated Analyzer (Hematofluorometry)
Biomarkers
LOINC Codes
- 2895-1 - ZPP RBC-mCnc
- 29763-0 - ZPP RBC-sRto
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
6 mL
Minimum Volume
0.2 mL
Container
Lavender (EDTA), royal blue (K2EDTA), royal blue (NaHep), tan (K2EDTA) or pink (K2EDTA) tube
Storage Instructions
Refrigerated
Causes for Rejection
Clotted, frozen, or hemolyzed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 30 hours |
| Refrigerated | 5 weeks |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant