Oncology FISH Analysis - CBFB: inv(16) [AML]

Casandra

Casandra Test Code BA13282Version 1 (DRAFT)

Performing Lab

Lab Baylor GeneticsLab Test ID 8740CPT Codes 88237, 88271, 88275, 88291

Oncology FISH Analysis - CBFB: inv(16) [AML]

Clinical Use

Use

Oncology FISH Analysis - CBFB: inv(16) [AML] is a specialized test designed to detect a chromosomal inversion commonly associated with acute myeloid leukemia (AML). AML is a serious leukemia predominantly affecting adults, originating from undifferentiated white blood cells in the bone marrow that can infiltrate various organs such as the liver, CNS, and lymph nodes. This FISH test primarily identifies the inv(16) or t(16;16) involving the CBFB gene, which correlates with favorable prognoses found in 5-8% of AML cases. Interpretation of results must be contextualized with clinical and pathological data, enhancing diagnostic accuracy in patients exhibiting symptoms or anomalies related to AML.

Special Instructions

This assay is implemented in various clinical situations, including when cytogenetic testing results are inconclusive, or for monitoring treatment responses. Proper specimen handling is essential to ensure the most accurate outcomes.

Limitations

This assay is limited to detecting specific rearrangements involving the CBFB locus. It cannot identify translocations involving other partner chromosomes, which may be crucial for comprehensive AML diagnostics. Results should supplement, rather than replace, other diagnostic approaches or tests, as they provide data specific only to the CBFB inversion and associated alterations.

Test Details