Periodic Fever Syndromes Panel (7 genes)
Use
The Periodic Fever Syndromes Panel evaluates genetic variants in seven genes associated with inherited autoinflammatory periodic fever disorders, including familial Mediterranean fever, hyper-IgD syndrome, TRAPS (Familial Hibernian fever), Muckle–Wells syndrome (familial cold urticaria/NOMID), cyclic neutropenia, PAPA syndrome, and Majeed syndrome. Clinical testing helps elucidate underlying genetic etiology in patients with recurring febrile episodes suggestive of periodic fever syndromes.
Special Instructions
GeneDx regularly updates panel gene composition and technical limitations. Ordering requires use of the GeneDx test requisition form (rare disorders TRF) — code 367 for this panel. Ensure clinical history is provided to support test interpretation.
Limitations
Panel gene content, versions, and test limitations may change over time; refer to the GeneDx website or current test requisition form for the most up-to-date gene list and limitations ([genedx.com](https://www.genedx.com/wp-content/uploads/2025/09/67904-Rare-TRF-v250601.pdf?utm_source=openai)).
Methodology
NGS (Targeted)
Biomarkers
Result Turnaround Time
21 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided