Allergen Profile, Walnut, IgE With Component Reflex
Use
The measurement of specific immunoglobulin E (IgE) to individual components of an allergen, either purified native or recombinant, is referred to as component resolved diagnosis (CRD).1-5 This approach represents an improvement over traditional measurement of IgE to allergen extracts that contain a mixture of proteins. The pattern of specific IgE reactivity to component allergens can predict which patients are at higher risk for systemic allergic reactions versus those who are sensitized but clinically tolerant. CRD can also be used to predict which patients are at risk for more severe reactions and which patients are likely to have milder symptoms.
Special Instructions
Testing involves the measurement of allergen-specific IgE to walnut extract, reflexing to two molecular components. Turnaround time is typically 3 to 5 days, but additional time may be needed for extra confirmatory tests.
Limitations
While component IgE testing enhances the evaluation of potentially allergic individuals, it does not replace clinical history or oral food challenge. The patient's age, other conditions like atopic dermatitis, and regular diet history are critical for an accurate diagnosis. An undetectable food-specific IgE result does not rule out allergy if clinical suspicion exists.
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 8251-1
- 6273-7
- 81790-8
- 81789-0
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.6 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature