ANA by IFA, Reflex to 9-biomarker profile, dsDNA, RNP, Sm, SS-A, SS-B, Scl-70, Chromatin, Jo-1, Centromere B by Multiplex Immunoassay
Also known as: ANA IFA Reflex
Use
Assay for screening for ANAs in patients suspected of having connective tissue disease.
Special Instructions
Not provided.
Limitations
Males and females older than 80 years of age have a 50% incidence of low titer ANA. The test may report positive due to certain medications that induce a 'lupoid' condition; however, the titer usually decreases following the withdrawal of the drug. Additionally, low antibody levels may also be present in conditions other than connective tissue diseases. A negative test is strong evidence against SLE, but it is not conclusive.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 42254-3 - ANA Ser Ql IF
- 77202-0 - Laboratory comment Report
- 20398-4 - ANA Homogen Titr Ser
- 20399-2 - ANA nucleolar Titr Ser
- 20401-6 - ANA Speckled Titr Ser
- 5077-3 - Centromere Ab Titr Ser IF
- 53003-0 - Mitotic spindle app Ab Titr SerPl IF
- 54006-2 - ANA nuclear membrane pores Titr Ser IF
- 54155-7 - ANA intercell bridge Titr Ser IF
- 53998-1 - ANA nuclear dots Titr Ser IF
- 53006-3 - ENA PCNA Ab Titr Ser IF
- 53993-2 - ANA centrosomal Titr Ser IF
- 8251-1 - Service Cmnt-Imp
- 5130-0 - dsDNA Ab Ser-aCnc
- 29374-6 - ENA RNP Ab Ser-aCnc
- 11090-8 - ENA SM Ab Ser-aCnc
- 27416-7 - ENA Scl70 Ab Ser-aCnc
- 17792-3 - ENA SS-A Ab Ser-aCnc
- 17791-5 - ENA SS-B Ab Ser-aCnc
- 51775-5 - Chromatin Ab SerPl-aCnc
- 11565-9 - ENA Jo1 Ab Ser-aCnc
- 53982-5 - Centromere B Ab Ser-aCnc
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | 7 days |
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