Anti-Centromere Ab by IFA (RDL)
Also known as: Centromere
Use
The most common setting for finding anti-centromere antibodies is in patients with a limited cutaneous form of scleroderma. Anti-centromere abs are found in 22% of patients with systemic sclerosis and in 12% of patients with primary biliary cirrhosis, and are rarely present in normal individuals.
Special Instructions
Not provided.
Limitations
Anti-centromere antibodies are found in 46% of patients with Limited Systemic Sclerosis and 11% in Diffuse Systemic Sclerosis. The accuracy of this test may be influenced by sample integrity; grossly hemolyzed, bacterial contamination, lipemic, icteric, and non-serum specimen types are causes for rejection. The sample stability is contingent on proper storage, with room temperature stability for 7 days, refrigerated for 14 days, and frozen for 60 days, stable through one freeze/thaw cycle.
Methodology
Immunoassay (Indirect fluorescent antibody (IFA))
Biomarkers
Anti-Centromere Ab
Protein
LOINC Codes
- 5077-3 - Centromere Ab Titr Ser IF
- 5077-3 - Centromere Ab Titr Ser IF
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |
Other tests from different labs that may be relevant