Anti-Müllerian Hormone (AMH) (Endocrine Sciences)
Also known as: Müllerian-inhibiting Substance
Use
The Anti-Müllerian Hormone (AMH) test is used to evaluate ovarian reserve and can help predict the onset of menopause. It is also utilized in reproductive endocrinology to assess ovarian function and response to fertility treatments. AMH levels are relevant for determining gonadotrophin doses for ovarian stimulation and evaluating live birth chances in women with diminished ovarian reserve. It is beneficial in assessing reproductive decline with age, particularly in women with proven fertility. Elevated AMH levels can indicate ovarian hyperstimulation syndrome or polycystic ovarian syndrome (PCOS).
Special Instructions
For accurate results, transfer the specimen to a plastic transport tube before freezing. Submit separate frozen specimens if multiple tests are requested to avoid delays in turnaround time.
Limitations
The test is not FDA-cleared or approved and may experience interference by heterophile antibodies in the sample. Elevated AMH is not specific for malignancy and should not be used to exclusively diagnose or rule out AMH-secreting ovarian tumors. AMH levels in PCOS patients can be 2 to 5 fold higher than age-appropriate reference interval values.
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 38476-8
- 38476-8
Result Turnaround Time
4-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Transfer specimen to a plastic transport tube before freezing. To avoid delays when requesting multiple tests, submit separate frozen specimens for each test requested.
Storage Instructions
Freeze.
Causes for Rejection
Gross hemolysis; gross lipemia; specimen at room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 day |
| Refrigerated | 14 days |
| Frozen | 14 days |