AspirinWorks® (11-Dehydro Thromboxane B2)
Also known as: 11-Dehydro Thromboxane B2, 11dhTxB2
Use
A means to assess aspirin effect.
Special Instructions
Label a urine collection cup with the patient's name and provide instructions for collecting a random urine sample. Transfer the urine into an appropriate transport tube containing preservative and freeze it. Ensure the sample is not diluted and follow specified storage instructions.
Limitations
Urine samples that are too dilute will not yield accurate results. Approximately 30% of urinary 11-dehydro TxB2 may be derived from extra platelet sources, such as monocytes and macrophages, which can generate additional COX-1 following aspirin inhibition, whereas platelets cannot. Elevated levels may occur with inflammatory conditions, potentially underestimating aspirin's effect on platelet COX-1.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 49734-7
- 49734-7
Result Turnaround Time
4-9 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
9 mL
Minimum Volume
6 mL
Container
Urine collection cup and transfer tube with preservative, such as BD C&S Vacutainer® tubes, BD UAP Vacutainer® tubes, or Aspirin Works™ tubes containing Chlorstat tablets.
Collection Instructions
Label a urine collection cup with the patient's name and provide instructions for random urine sample collection. Transfer urine within 24 hours of collection into the transport tube with preservative, fill to approximately 9 mL and no less than 6 mL, seal tightly, invert, and freeze.
Storage Instructions
Freeze on arrival at Labcorp. Stable refrigerated for 24 hours.
Causes for Rejection
Improperly labeled specimens; insufficient quantity received; tube incompletely filled; urine specimen not frozen; sample too dilute
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 24 hours |