Coenzyme Q10, Total

Also known as: CoQ10, Ubiquinone 50

Clinical Use

Use

Coenzyme Q10 (CoQ10) is also referred to as ubiquinone because it can be found in almost all eukaryotic cells.1 CoQ10 embedded in the inner mitochondrial membrane is an essential component of the electron transport chain and plays a role in the ATP-producing oxidative phosphorylation.1 CoQ10 is also a powerful lipid-soluble antioxidant protecting cell membranes and lipoproteins.1 CoQ10 is present in the plasma in both the reduced (ubiquinol) and oxidized (ubiquinone) forms.2 The reduced form of CoQ10 is the only endogenously synthesized lipophilic antioxidant and as such, serves to protect biological membranes against oxidation as well as inhibiting the peroxidation of lipoproteins in the circulation.2 Reduced CoQ10 in plasma may also have a role recycling vitamin E (alpha-tocopherol).3

Special Instructions

Not provided.

Limitations

This test has not been cleared or approved by the FDA, and its performance characteristics were determined by LabCorp. Testing involves measuring both reduced and oxidized forms of CoQ10 in the plasma. Variability in CoQ10 levels may be due to statin medication or dietary sources, primarily meat products. Samples not protected from light are unsuitable, as the sample's validity relies on its stability and proper handling.

Test Details

Methodology

Mass Spectrometry

Biomarkers

LOINC Codes

Order Codes

27923-2 - Ubiquinone10 SerPl-mCnc

Result Codes

27923-2 - Ubiquinone10 SerPl-mCnc

Result Turnaround Time

4-6 days

Specimen

Serum

Volume

0.5 mL

Minimum Volume

0.25 mL

Container

Serum gel-barrier tube or red-top tube

Collection Instructions

Collect the specimen in a serum gel tube or red-top tube, then transfer the serum into an amber plastic transport tube (LabCorp order no. 23598). Protect from light.