Coenzyme Q10, Total
Also known as: CoQ10, Ubiquinone 50
Use
Coenzyme Q10 (CoQ10) is also referred to as ubiquinone because it can be found in almost all eukaryotic cells.1 CoQ10 embedded in the inner mitochondrial membrane is an essential component of the electron transport chain and plays a role in the ATP-producing oxidative phosphorylation.1 CoQ10 is also a powerful lipid-soluble antioxidant protecting cell membranes and lipoproteins.1 CoQ10 is present in the plasma in both the reduced (ubiquinol) and oxidized (ubiquinone) forms.2 The reduced form of CoQ10 is the only endogenously synthesized lipophilic antioxidant and as such, serves to protect biological membranes against oxidation as well as inhibiting the peroxidation of lipoproteins in the circulation.2 Reduced CoQ10 in plasma may also have a role recycling vitamin E (alpha-tocopherol).3
Special Instructions
CoQ10 supplements are available over the counter and are used clinically for various conditions. The test results may be affected by statin therapy since it is known to lower CoQ10 plasma levels. Samples must be protected from light during collection and transport to ensure the integrity of the measurement.
Limitations
This test has not been cleared or approved by the FDA, and its performance characteristics were determined by LabCorp. Testing involves measuring both reduced and oxidized forms of CoQ10 in the plasma. Variability in CoQ10 levels may be due to statin medication or dietary sources, primarily meat products. Samples not protected from light are unsuitable, as the sample's validity relies on its stability and proper handling.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 27923-2
- 27923-2
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.25 mL
Container
Serum gel-barrier tube or red-top tube
Collection Instructions
Collect the specimen in a serum gel tube or red-top tube, then transfer the serum into an amber plastic transport tube (LabCorp order no. 23598). Protect from light.
Storage Instructions
Refrigerate after collection.
Causes for Rejection
Non-light-protected serum
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 3 days |
| Refrigerated | 14 days |
| Frozen | 14 days |