Coxsackie A Virus Antibody Profile, IgG, IgM
Also known as: Hand, Foot, and Mouth Disease
Use
This assay uses indirect immunofluorescence to determine IgG and IgM titers to Coxsackie A serotypes A7, A9, A16, and A24. Recent infections of Coxsackie viruses are characterized by elevated titers of IgG and IgM.
Special Instructions
Coxsackie viruses belong to the Picornavirus family and exhibit a variety of serotypes and strains. Proper specimen collection and timing are important for accurate results, particularly in detecting recent infections. If early infection is suspected, a follow-up specimen collection after 10 to 20 days is recommended.
Limitations
A positive result does not unequivocally indicate a current or recent infection. Antibodies can be present in individuals due to moderate passive exposure instead of an active infection. Hence, clinical correlation is required to avoid misinterpretation, particularly since samples collected early in the infection might not have detectable antibodies. Also, false negatives could occur if testing is not conducted at an appropriate stage of the infection.
Methodology
Immunoassay (IFA)
Biomarkers
LOINC Codes
- 59584-3
- 58792-3
- 59583-5
- 59582-7
- 59581-9
- 58791-5
- 59580-1
- 59579-3
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Gel-barrier tube or red-top tube
Storage Instructions
Room temperature
Causes for Rejection
Microbially-contaminated or heat-treated specimen; specimen containing particulate matter; grossly hemolyzed, lipemic, or icteric samples
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |