Coxsackie A Virus Antibody Profile, IgM
Also known as: Hand, Foot, and Mouth Disease
Use
This assay uses indirect immunofluorescence to determine IgM titers to Coxsackie A serotypes A7, A9, A16, and A24. Recent infections of Coxsackie viruses are characterized by elevated titers of IgG and IgM.
Special Instructions
Not provided.
Limitations
A positive test result does not necessarily indicate current or recent infection as antibodies can be detected due to moderate passive exposure to infected hosts. Results should be correlated with the clinical history and other data available to the physician. Early-stage infection samples (primarily in children) may not yield detectable antibodies. If a recent infection is suspected, a second specimen should be collected 10 to 20 days following the initial one for testing.
Methodology
Immunoassay (Indirect fluorescent antibody (IFA))
Biomarkers
LOINC Codes
- 59581-9 - CV A7 IgM Titr Ser IF
- 58791-5 - CV A9 IgM Titr Ser IF
- 59580-1 - CV A16 IgM Titr Ser IF
- 59579-3 - CV A24 IgM Titr Ser IF
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Gel-barrier tube or red-top tube
Storage Instructions
Room temperature
Causes for Rejection
Microbially-contaminated or heat-treated specimen; specimen containing particulate matter; grossly hemolyzed, lipemic, or icteric samples
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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