Dibucaine Number
Also known as: Dibucaine Inhibition
Use
Assess the presence of homozygous or heterozygous “atypical” cholinesterase variant, in patients who have low result of serum or plasma cholinesterase assay, and may be at risk of apnea when given succinylcholine muscle relaxant
Special Instructions
Mark transport tube appropriately as 'serum' or 'plasma'. Do not collect within 24 hours of administration of muscle relaxant.
Limitations
No single simple test currently exists that can detect all enzyme variants. The dibucaine number approach does not entirely avoid the problem of variation in reactivity with some atypical enzymes. Sensitivity is determined by genetic control and specific genetic variants are not detectable through this method.
Methodology
Other
Biomarkers
LOINC Codes
- 39354-6
- 39354-6
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.2 mL
Container
Red-top tube, gel-barrier tube
Collection Instructions
Separate serum or plasma from cells and place in transport tube.
Patient Preparation
Do not collect within 24 hours of administration of muscle relaxant.
Storage Instructions
Room temperature
Causes for Rejection
Plasma or serum not separated from cells; frozen whole blood received; hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |