Meningitis/Encephalitis Pathogen Panel, NAA, Cerebrospinal Fluid (CSF)

Also known as: FilmArray, ME CSF Panel by NAA, Meningitis/Encephalitis CSF Panel by NAA

Clinical Use

Use

This test is used as an aid in the diagnosis of specific agents of meningitis and/or encephalitis; results are meant to be used in conjunction with other clinical, epidemiological and laboratory data.

Special Instructions

Not provided.

Limitations

Results are not intended to be used solely for diagnosis, treatment, or other patient management decisions. Positive results do not rule out co-infection with organisms not included in the FilmArray ME Panel. The presence of a detected agent may not be the cause of the disease, and negative results do not preclude a central nervous system infection. Some herpesviruses may reactivate in various clinical settings, and interpretation should be done with clinical context and expert consultation. Sensitivity in clinical use may differ from that in the package insert.

Test Details

Methodology

PCR-based (Multiplexed nucleic acid amplification)

Biomarkers

14 targets

Cryptococcus neoformans/gattiiCytomegalovirusEnterovirusEscherichia coli K1Haemophilus influenzaeHerpes simplex virus 1Herpes simplex virus 2Human herpesvirus 6+6 more

LOINC Codes

Order Codes

82180-1 - Mening+Enc Pnl CSF NAA+n-prb

Result Codes

82191-8 - HSV2 DNA CSF Ql NAA+n-prb
82192-6 - HHV6 DNA CSF Ql NAA+n-prb
82193-4 - Parechovirus A RNA CSF Ql NAA+n-prb
82188-4 - VZV DNA CSF Ql NAA+n-prb
82181-9 - C gattii+neofor DNA CSF Ql NAA+n-prb
82182-7 - E coli K1 DNA CSF Ql NAA+n-prb
82183-5 - Haem influ DNA CSF Ql NAA+n-prb
82184-3 - L monocytog DNA CSF Ql NAA+n-prb
82185-0 - N men DNA CSF Ql NAA+n-prb
82186-8 - Gp B Strep DNA CSF Ql NAA+n-prb
82187-6 - S pneum DNA CSF Ql NAA+n-prb
82189-2 - CMV DNA CSF Ql NAA+n-prb
82194-2 - EV RNA CSF Ql NAA+n-prb
82190-0 - HSV1 DNA CSF Ql NAA+n-prb

Result Turnaround Time

0-1 day

Specimen

Cerebrospinal Fluid

Volume

1 mL unspun CSF

Minimum Volume

0.2 mL unspun CSF

Container

Sterile CSF tube, no preservative or additive

Collection Instructions

Collect specimen via lumbar puncture; do not centrifuge the specimen.

Storage Instructions

Refrigerate.

Causes for Rejection

Specimen stored at room temperature more than 24 hours or specimen stored refrigerated longer than 7 days; specimen other than CSF; specimen centrifuged