Muscle Specific Kinase (MuSK) Antibodies
Also known as: AChR seronegative MG, Anti-MuSK, MG, MG antibodies, Myasthenia Gravis
Use
Diagnosis of muscle‐specific kinase (MuSK) myasthenia gravis.
Special Instructions
Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection. Send serum in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Limitations
Immunosuppressant therapy is a common cause of false-seronegativity. A patient's characteristics of myasthenia gravis may be obscured by superimposed steroid-induced myopathy. Though a positive MuSK result is specific for the diagnosis of MuSK myasthenia gravis (MG), a negative result does not rule out an MG diagnosis.
Methodology
Immunoassay (Radioimmunoprecipitation Assay (RIPA))
Biomarkers
LOINC Codes
- 57436-8
- 57436-8
Result Turnaround Time
7-11 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection. Send serum in a plastic transport tube.
Storage Instructions
Refrigerated or frozen
Causes for Rejection
Grossly hemolytic or lipemic sample will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 1 year |